In a recent study published in the medRxiv preprint server, researchers assess the effect of nirmatrelvir plus ritonavir (NMV-r) on the onset of post-acute sequelae of severe acute respiratory syndrome coronavirus 2-infection (PASC) aka long coronavirus disease 2019 (COVID-19).
The global burden of PASC is rising rapidly, which will cause adverse public healthcare and economic impact. NMV-r is now a popular antiviral therapy for outpatient mild-to-moderate COVID-19 cases, including unvaccinated patients.
A recent study assessed the incidence of PASC-related symptoms in people treated with NMV-r. It included 279,380 vaccinated adults above 18 years of age who suffered from COVID-19 infection and received NMV-r within five days of diagnosis and did not seek hospitalization throughout the study duration.
The researchers discovered that only 1,004 individuals received NMV-r within five days of diagnosis. Between 30 to 180 days post-infection (pi), PASC-related symptoms occurred in 42% and 48%of NMV-r and control patients, respectively. NMV-r therapy showed to reduce the risk of cardiovascular, respiratory, and gastrointestinal symptoms, anxiety, or mood disorders but had no marked effects on musculoskeletal and nervous system symptoms. NMV-r therapy also showed a lower association with a narrow definition of a three-symptom cluster of PASC than the control.
The study confirmed that NMV-r therapy could reduce the incidence of most commonly reported PASC-related symptoms, thus, has a promising clinical implication.
Subscribe To Our Newsletter
Filter out the noise and nurture your inbox with health and wellness advice that's inclusive and rooted in medical expertise.
Medtalks is India's fastest growing Healthcare Learning and Patient Education Platform designed and developed to help doctors and other medical professionals to cater educational and training needs and to discover, discuss and learn the latest and best practices across 100+ medical specialties. Also find India Healthcare Latest Health News & Updates on the India Healthcare at Medtalks
Please update your details
Please login to comment on this article