Acute Cheilitis with Oseltamivir

A report describes a case of an 11-year-old girl who presented with lower lip cheilitis and stomatitis for a day. There was no history of any such previous episodes, and none of the other body parts were affected. She was taking oseltamivir capsules (75 mg twice daily) 2 days before the swelling began. The patient had visited a primary care doctor with a bout of seasonal influenza with fever, cough, and arthralgia, which was relieved with Oseltamivir. Concomitantly, she also took an expectorant (dextromethorphan) and an anti-inflammatory drug (tiaramide hydrochloride) for two days. She has a history of expectorant and anti-inflammatory drug consumption many times before that did not cause any problems. 

Examination showed the patient to be febrile (38.0°C), with a white swollen lip, ulcerated labia, and bilateral cervical lymphadenopathy. Other physical examinations were unremarkable.

Laboratory investigations showed leukopenia, neutrophil granulocytes, elevated C-reactive protein, and no vitamin deficiencies. Comprehensive respiratory virus testing or antibody titer studies showed no significant results. 

She was advised to stop Oseltamivir and treated with an expectorant and anti-inflammatory drug, which resolved her symptoms and signs within 36 hours. There was no recurrence of symptoms till a year later. 

Yokoyama K, Mamada M. Acute Cheilitis Associated with Oseltamivir after Influenzae A Infection. Case Reports in Pediatrics. 2023;2023. https://doi.org/10.1155/2023/8618245