Biochemical Investigations in Hyperlipidemia

Biochemical Investigations in Hyperlipidemia

  1. Hyperlipidemia/Dyslipidemia investigations:

  1. Tests that establish primary/secondary cause for Hyperlipidemia/Dyslipidemia

  2. Tests that establish additional risks related to Dyslipidemia

  3. Lipid-related

  4. Non-lipid-related 

  1. Dyslipidemia Investigations:

  1. Biochemical

  2. Genetic

  1. Imaging modalities in assessing consequences of Dyslipidemia.

  2. Secondary causes may be ruled out using urine dipstick, thyroid function tests, liver tests, glucose, Glycated haemoglobin and protein electrophoresis.

  3. Certain medical conditions that increase CVD risk are NAFLD, OSAS, PCOS, GDM, PIH, PAD, inflammatory arthritis, organ transplantation and immunosuppression, CKD and drug use.

  4. Investigations into specific forms of Hyperlipidemia:

  1. Familial Hypercholesterolemia – full lipid profile and lipoprotein, most international guidelines recommend genetic testing that involves sequencing of LDL receptor, apoB and PCSK9 genes.

  2. Familial combined Hyperlipidemia – full lipid profile and lipoprotein; genetic testing is not available-polygenic.

Dr. Devaki R Nair

Dr. Devaki R Nair is a Consultant Chemical Pathologist and Clinical Lead for Clinical biochemistry Royal Free hospital and North Middlesex University Hospital. She is Completed BSc MSc MBBS FRCP FRCPath and Director SAS Centre for Cardiovascular Biomarkers, Training Programme Director for Chemical Pathology and Metabolic Medicine; Speciality Lead for Biochemistry HSL. She is involved in conducting many clinical trials for novel lipid-lowering drugs as chief investigator and as principal investigator. She set up one of the first family support centre for FH and was awarded a BHF grant for cascade testing.

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