Newer drugs in clinical practice
Angiopoietin-like protein 3 (ANGPTL3) is a key modulator of plasma lipoprotein levels. Evinacumab is a full human monoclonal antibody and inhibits ANGPTL3.
Three new drugs targeting Lp(a) are in development; all siRNA-based therapies: Pelacarsen, Olpasiran and SLN360.
Obicetrapib is a selective cholesteryl ester transfer protein (CETP) inhibitor; a daily dose of 10 mg obicetrapib in combination with moderate-intensity statins for 12 weeks resulted in an incremental LDL-C reduction of up to 50% compared with statin monotherapy.
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