Biochemistry and Genetics of Triglyceride
- Triglycerides (TGs) consist of fatty acids linked to one glycerol.
- TGs are transported as core constituents of all lipoproteins.
- TGs are hydrolyzed by LPL.
- Pathogenic mutations in LPL, ApoC2, GPIHBP1, LMF1 and ApoA-V are the causes of monogenic chylomicronemia.
- For treating familial chylomicronemia, dietary modification and lipid-lowering drugs, including fibrates, niacin and omega-3 fatty acids, are used, which have less efficacy.
- For the treatment of familial chylomicronemia, anti-APOC3 antisense has been developed.
- Several autoimmune diseases may cause hyperchylomicronemia due to anti- GPIHBP1.
Dr. Mariko Harada-Shiba
Dr. Mariko Harada-Shiba is a Director Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute. Mariko Harada-Shiba received her MD from Shiga University of Medical Science in 1984 and PhD in 1988. She then held a Post-Doctoral and Research Associate position in the Department of Etiology and Pathophysiology (Dr. Akira Yamamoto's lab) in National Cardiovascular Center and studied LDL apheresis therapy in homozygous and heterozygous FH patients. In 1996, she joined the Department of Biochemistry (Dr. Richard Hanson's lab) in Case Western Reserve University in USA. Now, she is the Director of the Department of Molecular Innovation in Lipidology in National Cerebral and Cardiovascular Center. She is a Council member of Science Council of Japan, a Board Director of Japan Apheresis Society and a Council Member of Japan Atherosclerosis Society.
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