Safety Profiles of Methotrexate Regimens in Ectopic Pregnancy Management
  
Safety Profiles of Methotrexate Regimens in Ectopic Pregnancy Management
Written By: user IJCP Editorial Team
Published On: 28 Nov, 2025 11:58 AM | Updated On: 19 Jan, 2026 4:48 PM

Safety Profiles of Methotrexate Regimens in Ectopic Pregnancy Management

Women diagnosed with ectopic pregnancy (EP) have to take methotrexate and are often concerned with its side effects. The present study evaluated the potential effects of methotrexate (MTX) single and multi-dose exposures on the ovarian reserve. It measured Follicle stimulation hormone (FSH), estradiol plasma levels (on day 3 of the cycle), and Anti-Mullerian Hormone (AMH) two times before MTX administration (pre-treatment) and eight weeks after treatment (post-treatment). It also evaluated antral follicle count (AFC) by trans-vaginal ultrasound pre- and post-treatment and found-

  • No difference in levels of FSH, AMH, and AFC between single-dose and multiple-dose groups. 
  • Significant difference in estradiol levels between the two groups, with higher estradiol concentrations in the multiple-dose MTX group.

This study shows that MTX administration, irrespective of the number of doses, has no negative effect on ovarian reserve and can safely treat EP.

Source:. J Obstet Gynecol India. 2024. https://doi.org/10.1007/s13224-023-01939-5

user
IJCP Editorial Team

Comprising seasoned professionals and experts from the medical field, the IJCP editorial team is dedicated to delivering timely and accurate content and thriving to provide attention-grabbing information for the readers. What sets them apart are their diverse expertise, spanning academia, research, and clinical practice, and their dedication to upholding the highest standards of quality and integrity. With a wealth of experience and a commitment to excellence, the IJCP editorial team strives to provide valuable perspectives, the latest trends, and in-depth analyses across various medical domains, all in a way that keeps you interested and engaged.

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