Published On: 25 Sep, 2024 1:43 PM | Updated On: 15 Feb, 2025 1:55 AM

Effects of Fenugreek and Metformin on Clinical and Metabolic Status of PCOS

Fenugreek seeds are believed to be high in fiber and possess anti-diabetic properties, potentially aiding blood glucose level reduction in women with polycystic ovary syndrome (PCOS). A recent study compared the clinical and metabolic effects of fenugreek with those of metformin in women aged 16-40 years with PCOS.

This was a randomized, triple-blinded, parallel clinical trial, wherein 55 women with PCOS were given fenugreek 333 mg, while another 55 received metformin 500 mg––both taken three times daily. Clinical and metabolic outcomes were assessed at the start of the trial and after two months of intervention.

The results depicted significant improvements in all evaluated factors in both groups – by the end of the study. Metformin was more effective in reducing biometric indices such as body mass index (BMI), waist-hip ratio, fasting blood sugar (FBS), and insulin resistance. Additionally, metformin significantly improved menstrual irregularities. However, fenugreek was superior in improving lipid profiles, including reductions in low-density lipoprotein (LDL) and triglycerides (TG), and an increase in high-density lipoprotein (HDL). Both treatments showed improvements in hair loss and hirsutism.

Although fenugreek cannot replace metformin in managing hyperglycemia related to PCOS, it offers benefits as an adjunct therapy, particularly for patients with hyperlipidemia and severe hair loss. The study demonstrated that two months of fenugreek supplementation led to significant improvements in glycemic control, lipid profiles, and hair loss reduction. Its lipid-lowering effects and lower incidence of side effects make fenugreek a promising complementary treatment option for improving the metabolic status of women with PCOS.

Source: Mirgaloybayat S, Akbari Sene A, Jayervand F, et al. J Reprod Infertil. 2024;25(2):120-132. doi:10.18502/jri.v25i2.16040

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