Published On: 18 Aug, 2022 11:07 AM | Updated On: 07 Dec, 2024 11:38 AM
Statins and NAFLD
Nonalcoholic fatty liver disease (NAFLD) is associated with metabolic factors, and insulin resistance, type 2 diabetes and CVD are the most common cause of death.
NAFLD-important health issue in India.
Statins are used to treat atherogenic dyslipidemia to reduce ASCVD.
Statins may improve liver enzymes and histology in NAFLD.
Treatment with statins may have beneficial effects on NAFLD and its liverrelated complications, notably including cirrhosis, portal hypertension and hepatocellular carcinoma (HCC).
Indeed, further to their lipid-lowering activity, statins also exert several systemic pleiotropic mechanisms that collectively may occur in improving steatosis, sterile inflammation, fibrosis and tumorigenesis.
Statins elevate liver enzymes leading to significant concern among physicians to prescribe statins in NAFLD are significantly underused in NAFLD and nonalcoholic steatohepatitis (NASH).
Evidence suggests that the risk for serious liver injury from statins is quite rare, and patients with NAFLD and dyslipidemia are not at increased risk for statin-induced hepatotoxicity.
Hence, statins could be used by physicians to treat dyslipidemia in patients with NAFLD.
Paucity of data to suggest the usage of statins as a treatment option for NAFLD. However, it continues to be a matter of debate, and treatment of NAFLD with statins cannot be recommended at present.
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