Statin Intolerance

Statin Intolerance

  1. Statins are the most common, widely prescribed first choice medication for lipid-lowering.
  2. Inability to take statins to achieve the target LDL-C for the individual.
  3. Inability is due to adverse effects or due to unacceptable elevation of liver enzymes or creative kinase levels.
  4. Absence of factors that can provoke the adverse effects of statins.
  5. Reversal on withdrawal.
  6. Failure to tolerate statins despite rechallenge.
  7. Intolerance to at least two statins – one at the lowest starting dose and another at any dose.
  8. Statin associated muscle side effects: The entire spectrum of muscular symptoms related to statin intake are now termed as statin associated muscle symptoms; 60% of statin discontinuation.
  9. Nutraceuticals are useful in:

       a. Managing residual risk associated with lipids other than LDL-C

       b. Managing nonlipid-mediated residual risk

       c. Optimizing LDL-C treatment in statin intolerance

       d. Optimizing LDL-C treatment when add-on therapies for statins are not available

       e. Adjuncts to lifestyle for individuals at high lifetime risk of ASCVD.

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