Published On: 10 Dec, 2024 5:58 PM | Updated On: 10 Dec, 2024 6:08 PM
Relationship Between Skin Manifestations and Body Mass Index, Blood Glucose, and Hormonal Levels in Patients with PCOD
Polycystic ovarian disease (PCOD) is typified by oligo/anovulation, ultrasound findings of polycystic ovaries, and skin-related symptoms including hirsutism, acne, acanthosis nigricans, androgenetic alopecia, and signs of virilization.
The present study was aimed the association between dermatological manifestations and body mass index (BMI), blood glucose, and levels of free testosterone, dehydroepiandrosterone sulfate (DHEAS), follicle stimulating hormone (FSH), and luteinizing hormone (LH) in patients of PCOD. This observational study was conducted from November 2015 to April 2017, involving 102 non-pregnant PCOD patients aged between 12 and 45 years. Participants' socio-demographic, menstrual, and medical histories were recorded, BMI was calculated, and skin manifestations were examined. Subsequently, pelvic ultrasound and assessments of blood sugar and hormone levels were performed.
The outcome revealed:
- The majority of participants (59.80%) were in their third decade of life and ultrasound indicated polycystic ovaries in 79.41% of cases.
- Skin manifestations were noted as follows: acne (74.50%), acanthosis nigricans (50%), striae (49.02%), hirsutism (40.19%), acrochordons (36.27%), seborrheic dermatitis (32.35%), and androgenetic alopecia (30.39%).
- Elevated levels of free testosterone (35; 34.31%), DHEAS (9; 8.82%), LH and FSH (2; 1.96% each), and a higher LH: FSH ratio (51; 50%) were observed.
- Remarkable associations were found between acanthosis nigricans and free testosterone, DHEAS, fasting blood sugar and increased BMI as well as between hirsutism, and elevated DHEAS, free testosterone, and BMI.
The study revealed significant associations between acanthosis nigricans and free testosterone, DHEAS, fasting blood sugar, and BMI, and between hirsutism and DHEAS, fee testosterone, and BMI.
Source: Sharma YK, Chauhan S, Singh P, Deo K. Correlation of Cutaneous Manifestations with Body Mass Index, Blood Glucose, and Hormonal Levels in Patients with Polycystic Ovarian Disease. Indian Dermatol Online J. 2020 May 10;11(3):378-381. doi: 10.4103/idoj.IDOJ_193_18. PMID: 32695697; PMCID: PMC7367582.
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