PVP-I Gargles: A Promising Antiseptic Shield against Whooping Cough

Bordetella pertussis, the causative agent of whooping cough, poses a significant threat to respiratory health in both children and adults. The present study investigated the bactericidal effectiveness of four antiseptics: povidone–iodine (PVP-I), benzethonium chloride (BEC), chlorhexidine gluconate (CHG), and benzalkonium chloride (BAC)—against B. pertussis ATCC9797 and clinical isolates.

Among the topical antiseptics investigated, PVP-I and BAC exhibited notably high bactericidal activity, contrasting with the relatively low activity observed for CHG. Furthermore, the PVP-I gargle demonstrated robust bactericidal efficacy, similar to topical PVP-I, while the BEC gargle exhibited diminished bactericidal activity.

These findings highlight the potential utility of topical PVP-I, as well as PVP-I gargle, as effective antiseptics in fighting B. pertussis.


Suzuki T, Kataoka H, Ida T, Mikuniya T, Suzuki T, Kamachi K. Bactericidal activity of topical antiseptics and their gargles against Bordetella pertussis. Journal of Infection and Chemotherapy. 2011;18(2):272-275. https://doi.org/10.1007/s10156-011-0312-4


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