Polycystic Ovary Syndrome Linked to Increased Suicide Risk Across Age Groups

Emerging evidence indicates that women with polycystic ovary syndrome (PCOS) face a significantly increased risk of suicide. A recent study published in Annals of Internal Medicine (Feb 6, 2024) reported that young women with PCOS are at least nine times more likely to attempt suicide, with a hazard ratio (HR) of 8.47.

The elevated risk is not limited to young adults. Among adolescents with PCOS, the HR was 5.38, while in older adult women, the HR remained substantial at 3.75. These findings suggest that mental health vulnerability in PCOS spans across age groups, highlighting the need for a lifespan approach to psychological care in this population.

PCOS is often associated with hormonal imbalances, metabolic disturbances, and psychosocial stressors—including body image concerns, infertility, and chronic symptoms such as hirsutism and irregular periods—which may contribute to heightened emotional distress. Anxiety, depression, and reduced quality of life are common comorbidities, further compounding suicide risk.

Given this evidence, healthcare providers managing women with PCOS should implement routine screening for mental health issues and suicidal ideation, alongside standard metabolic and reproductive assessments. Early recognition and timely psychological support, including counseling or psychiatric referral, could potentially prevent severe outcomes.

This study emphasizes that PCOS is not only an endocrine and metabolic disorder but also a condition with profound mental health implications. Integrating mental health care into routine PCOS management is essential for holistic care and improving patient outcomes.

Reference: Annals of Internal Medicine, Feb 6, 2024.