Management of Lean Patients with NAFLD (MASLD)

Management of Lean Patients with NAFLD (MASLD)

  • Lean nonalcoholic fatty liver disease (NAFLD) can progress to clinically significant liver disease without becoming obese.
  • Lean NAFLD patients have an improper lifestyle with more sedentary hours and higher dietary intake of free sugars and fructose. Exercise improves insulin resistance in these patients.
  • A healthy diet with curtailed free sugars is advised. It is difficult to recommend specific calorie restrictions in this group due to the scarcity of data.
  • Weight loss is the central pillar of NAFLD management in general, however, lean patients have normal body mass index (BMI). They need a lesser degree of weight loss to attain NAFLD remission compared to obese patients.
  • Indications for pharmacotherapy in lean NAFLD (MASLD) is likely similar to nonlean ones. Drugs like vitamin E, pioglitazone and saroglitazar can be used.

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