Hepatitis B virus (HBV) RNA and HBcrAg (Hepatitis B core-related antigen) are both biomarkers that are used to assess disease activity in chronic hepatitis B (CHB) infection. These biomarkers can help in determining the criteria to cess NA therapy. According to the Japanese HBV guidance, the criteria to cess NA therapy are: At least 2 years of administration of NAs. Undetectable serum HBV DNA level. Negative serum HBeAg at the time of treatment cessation.
However, in case, when these criteria are met, HBsAg and HBcrAg levels can be used to estimate the risk of relapse at the time of cessation. Some of the additional points to note about HBcrAg in CHB management are:
Dr. Norah Terrault is an Director of Viral Hepatitis Research in Liver Transplantation. She has completed B.MSc. University of Alberta,1987 M.D. University of Alberta,1997 M.P.H. University of California, Berkeley.
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