Endometrial carcinoma in a gravid uterus: a case report

A 32-year-old woman underwent an urgent cesarean delivery at 35 weeks of gestation due to antepartum bleeding caused by placenta previa. Post-delivery, hysterectomy was performed due to diagnosis of placenta accreta spectrum (PAS). 

The gross and histopathological examinations revealed an endometrioid adenocarcinoma (grade 1). The histopathological findings revealed a pattern similar to endometrial carcinoma (EC) – not related to pregnancy. 

Immunohistochemistry revealed an overexpression of the estrogen and progesterone receptors while the p53 expression was negative. 

Laparoscopic bilateral salpingo-oophorectomy and pelvic lymphadenectomy, after 3 months confirmed surgical stage IA without metastases. There was no recurrence at the 4-year follow-up.  

Evidence in literature suggests that EC cases are being diagnosed during or after pregnancy.