Obesity is a complex, multifactorial disease shaped by interactions between genetic susceptibility, neuroendocrine regulation, metabolic pathways, environmental exposures, and lifestyle factors. While genetic variation contributes to differences in adiposity, body-fat distribution, appetite regulation, and energy homeostasis, its clinical relevance in the assessment and management of obesity continues to evolve. Join Dr. Nishant Raizada for an evidence-based discussion on the genetic determinants of obesity, the mechanisms through which genetic factors influence energy balance and weight regulation, and the implications for clinical practice. Tune in to explore the current understanding of genetic risk, monogenic and polygenic obesity, and the potential role of precision approaches in obesity management!