New Lipid-lowering Drugs

New Lipid-lowering Drugs

1.    LDL-C is universally accepted as a major driver of atherosclerosis. Higher the baseline LDL, the higher the risk.

2.    Low and very low LDL levels are safe/effective in reducing CV events further, as shown by PCSK9 trials. Target LDL-C must be achieved in all patients with ASCVD.

3.    Lifestyle interventions remain the mainstay of management.

4.   High-dose statin is the first-line of therapy. Add ezetimibe in patients, not on goal. Either alone or in combination with statins, PCSK9 inhibitors reduce LDL by 60%.

5.    Bempedoic acid may be added if LDL-C reduction is required after statins and ezetimibe. PCSK9 inhibitor is indicated in selected patients.

Dr. Vimal Mehta

Prof Dr. Vimal Mehta is the Co-Founder & Chief Executive Officer at BioXcel Therapeutics & CEO, Chairman and Co-Founder. He Published a State of art paper in the Archives of Medical Science reviewing Pulmonary hypertension in left heart disease. Dr. Mehta holds a Ph.D. in chemistry from the University of Delhi, India and completed a Post-Doctoral Fellowship in chemistry at the University of Montpellier, France.

 More FAQs by Dr. Vimal Mehta

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