Moisturizer-Desonide Combo in Childhood Eczema: A Clinical Evaluation

Atopic dermatitis (AD), also known as atopic eczema, is a chronic, recurrent inflammatory skin disease affecting 15%-20% of children and 1%-3% of adults worldwide.

A real-world study examined the effectiveness and safety of using a soothing, moisturizing repair cream together with desonide for treating atopic dermatitis (AD) in children.

A total of 37 children with AD were randomly assigned to either an experimental group (17 children) or a control group (20 children). The experimental group received both the moisturizer and desonide cream during the treatment phase, followed by the moisturizer alone during the maintenance phase. The control group received only desonide during treatment, with no product used during maintenance.

Clinical evaluations were carried out before treatment and at 1, 2, and 4 weeks afterward. The treatment outcomes between the two groups were compared, with special attention to the moisturizer’s role in extending the maintenance period. Side effects were also monitored.

After 4 weeks, the experimental group showed a cure rate of 52.9% and an overall effectiveness rate of 100%. In contrast, the control group had a 0% cure rate and a 60% effectiveness rate. The median maintenance period was longer in the experimental group (73 days) compared to the control group (48 days). There was no significant difference in the rate of side effects between the groups.

These results suggest that combining a moisturizing repair cream with desonide is both effective and safe for treating childhood atopic dermatitis, and may help prolong the maintenance phase. This approach is promising for broader clinical use.

(Source: Medicine 104(3):p e41277, January 17, 2025. | DOI: 10.1097/MD.0000000000041277; https://journals.lww.com/md-journal/fulltext/2025/01170/study_on_the_clinical_efficacy_of_soothing.46.aspx?context=latestarticles)