1. Studies show 15% to 25% LDL-C reduction on background statin therapy; higher LDL-C reduction in patients not on statins.
2. Combination of bempedoic acid and ezetimibe lowers LDL-C by about 35% to 40%.
3. Bempedoic acid not activated in muscle.
4. Overall good safety profile: uric acid increase, small increased incidence of tendon rupture. Pending CV outcomes study.
Dr. P Barton Duell is a Professor of Medicine, Division of Cardiovascular Medicine, School of Medicine. He currently serves as the director of OHSU's Metabolic Disorders Clinic. He received his medical degree from OHSU in 1983, and completed his medicine residency at OHSU and the University of Chicago. He completed his metabolism, endocrinology and nutrition fellowship at the University of Washington in Seattle.
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