HELLP syndrome ‚Äď a severe pregnancy complication associated with hypertension, is characterized by hemolysis, elevated liver enzymes, and low platelets. The condition increases the risk for perinatal complications for the mother and offspring.¬†
The prevalence of HELLP syndrome is 0.2-0.8%, which often coexists with preeclampsia. Both preeclampsia and HELLP syndrome have a genetic predisposition while a history of HELLP pregnancy increases the preponderance of developing this entity in future pregnancies.¬†
Although a single genetic cause is yet to be identified, multiple gene variants imposing moderate risks along with maternal and environmental factors have been implicated in the etiology of HELLP.¬†¬†
The current review underscored the pathophysiological mechanism of HELLP syndrome. A better knowledge of the disease course is essential for its early detection, accurate diagnosis, and appropriate management of this condition.¬†
Source:¬†Medicina (Kaunas). 2022 Feb 21;58(2):326. doi: 10.3390/medicina58020326.
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