Infants born preterm are highly susceptible to infectious diseases, which many factors may contribute to; however, the immature nature of the preterm immune system remains one key factor.
A recent study used high-dimensional flow cytometry and cytokine assays to characterize the immune profiles in 25 preterms (range: 30.4-34.1 weeks gestational age) and 25-term infants (range: 37-40 weeks gestational age) in cord blood samples.
The study found that preterm infants have-
This study identified the key differences in pro-inflammatory immune profiles between preterm and term infants, thereby allowing for the development of targeted interventions to protect preterm infants who are more susceptible to infectious diseases during early life.
Source:. Front Immunol. 2021 Nov 1;12:777927. doi: 10.3389/fimmu.2021.777927. PMID: 34790206; PMCID: PMC8591285.
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