There is a lack of consensus regarding the definition of late-onset bacterial sepsis (LOS) in very preterm infants.
A recent study thus assessed the concordance of LOS diagnosis between experts in neonatal infection and international classifications and evaluated the potential impact on heart rate variability and rate of “bronchopulmonary dysplasia or death”.
This retrospective multicenter study included hospitalized infants born before 31 weeks of gestation. An intention to treat with antibiotics was performed for at least 5-days. LOS was either categorized as “certain or probable” or “doubtful” independently by five experts, employing four international classifications.
The results were as follows-
Thus, the definition of LOS was not found to be consensual, with a low international and moderate inter-observer agreement. This impacts the assessment of associated organ dysfunction and prognosis.
SOURCE= Bury G, Leroux S, Leon Borrego C, et al. Diagnosis of Neonatal Late-Onset Infection in Very Preterm Infant: Inter-Observer Agreement and International Classifications. Int J Environ Res Public Health. 2021;18(3):882. Published 2021 Jan 20. doi:10.3390/ijerph18030882
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