Addressing Vaginal Dryness in Reproductive-Aged Women: A Role for Hyaluronic Acid–Lactic Acid Suppositories

Vaginal dryness and discomfort are often under-recognized concerns among women of reproductive age, with substantial implications for sexual function and overall quality of life. An observational study involving 17 women aged 22 to 47 years demonstrated promising results using vaginal suppositories containing high molecular weight hyaluronic acid (10 mg) and racemic lactic acid (5 mg) over a 14–18 day period. Patients reported a marked reduction in symptoms such as dryness and itching by day 8, with near-complete resolution by day 20 in most participants. Additionally, improvements were noted in the Female Sexual Function Index (FSFI), particularly in the domains of lubrication, pain relief, and satisfaction, suggesting a meaningful enhancement in sexual health outcomes.

These findings reinforce the therapeutic utility of hyaluronic acid–lactic acid combinations in managing vulvovaginal dryness, even in non-menopausal populations. Incorporating such non-hormonal, biocompatible therapies into clinical practice may provide a safe, effective, and patient-friendly alternative for improving intimate health in women of reproductive age.

Source: Chernova, C. N., Dolya, D. O., Frigo, F. N., &Zadorozhnaya, Z. I. (2024). Moisturizers in the management of patients with complaints of dryness in the genital area. Akušerstvo I Ginekologiâ, 8_2024, 134–140. https://doi.org/10.18565/aig.2024.198