Pneumonia makes the top infectious cause of death in children, with especially high mortality in low- and middle-income countries. Interleukin-18 binding protein (IL-18BP), a natural antagonist of the proinflammatory cytokine interleukin-18, is raised in numerous autoimmune conditions and infectious diseases.Â
This prospective cohort study determined the association between admission IL-18BP levels and clinical severity among children admitted to two hospitals in Uganda for hypoxemic pneumonia. It included a total of 42 children (median age of 1.2 years). And found that-
This study shows that higher IL-18BP levels are associated with increased disease severity and prolonged recovery times in children with pneumonia.
Cytokine. 2022 Feb;150:155775. doi: 10.1016/j.cyto.2021.155775. Epub 2021 Dec 5. PMID: 34875584.
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