Obese patients with nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH) require an endoscopy balloon or gastroplasty with/without duodenal mucosal resurfacing (DMR), while lean patients with NAFLD/NASH require endoscopic DMR. Duodenum is at the center of metabolic control; a sustained glycemic improvement is seen even after 12 months after a single DMR. Duodenal nutrient passage strongly influences insulin sensitivity, independent of weight change. DMR is safe and yields beneficial disease-modifying metabolic effects, especially in patients with high fasting plasma glucose levels. The newer DMR therapies include Laser, radiofrequency ablation (RFA) and electroporation.
RECETTM is the first nonthermal endoscopic ablative therapy and, thus, the only therapy to ablate cells selectively. It is feasible with the technical success achieved in 100% of subjects. It is safe and well-tolerated, with a few mild to moderate and transient adverse events. No serious adverse events have been reported with RECETTM. Duodenal RECETTM results in durable and clinically meaningful improvement in glycemic control. A dose response has been observed, with higher energy doses being more effective without any increased risk of adverse events.
Dr. Nageshwar Reddy is currently the Chairman of Asian Institute of Gastroenterology and AIG Hospitals, Hyderabad, India. Past President of World Endoscopy Organization. He graduated from Kurnool Medical College obtaining internal medicine, Masters in Madras Medical College and D.M in Gastroenterology from PGIMER, Chandigarh. He subsequently worked as a Professor of Gastroenterology in Andhra Pradesh Health Sciences before setting up Asian Institute of Gastroenterology, a tertiary care Gastro intestinal Specialties Hospital. His main area of research interest has been in G.I. Endoscopy particularly in Therapeutic Pancreatio Biliary Endoscopy and Innovations in Transgastric Endoscopic Surgery. He has published over 670 papers in National & International Peer review journals and has contributed chapters in 20 International Text Books of Gastroenterology and has edited 8 G.I. Endoscopy Text Books.
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