Researchers in China have made an important breakthrough in treating Crohn's disease and ulcerative colitis, two chronic inflammatory diseases affecting millions of people. They have developed a microgel delivery system that enhances the effectiveness of probiotics in the gut while targeting and eliminating harmful gut bacteria associated with these conditions. Using a mouse model, the scientists demonstrated that the treated mice did not exhibit common colitis symptoms, such as damaged intestinal barriers or shortened colons.
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is characterized by an imbalance of bacteria in the gastrointestinal tract, which allows harmful bacteria to overpower beneficial ones, affecting the intestinal barrier function and immune responses. Immunosuppressant medications are commonly used to treat IBD, but they come with significant side effects and high costs.
Probiotics have shown the potential to improve IBD symptoms, but their efficacy is hindered by challenges in delivering them to the specific site in the intestine where they are needed. Factors such as gastric acid, bile salts, and intestinal contractions can impede the successful colonization of probiotics in the gut.
Scientists at Zhengzhou University have developed a probiotic oral gel to overcome these challenges. The gel effectively shields and protects the beneficial bacteria while neutralizing the harmful ones. This innovative approach allows the probiotics to reach the affected areas in the gut and restore balance.
The researchers believe this microgel delivery system holds promise as a potential treatment for colitis. It shows potential in restoring colonic health, regulating the inflammatory response, repairing the damaged mucosal barrier, and achieving gut microbiome homeostasis. While more advanced preclinical studies are needed to confirm these findings, this research offers a new perspective on using probiotics as a therapeutic approach for colitis.
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